Repeated IVF failure, can I benefit from PGD?

  1. avatar

    I had my 5th miscarriage one week ago and to be honest DH and I are devastated, we don’t know what to do or what’s next. Dr says we should give PGD a try, but what if the causes of failure are not genetic or chromosomal? What if they’re immunological?
    In any case, I’d like to learn more about the success rates of PGD, and also what’s your opinion taking our case into account? Do you think it’ll work for us? What about egg donation or surrogacy?

    01/08/2018 at 17:08
    #1115 Reply
  2. avatar
    Sandra F.
    Surrogacy Specialist

    Dear Noolaa,

    Recurrent miscarriages can occur due to multiple reasons, being one of them linked to the genes of the embryo. Some genetic abnormalities allow for fertilization and embryo development but it stops developing at some point early in pregnancy. In other words, embryonic arrest occurs very early in pregnancy, and that’s when we talk about miscarriage.

    If in your cause recurrent miscarriages occur due to a genetic problem, PGD could indeed be the solution for you. This genetic analysis is done prior to the transfer in order to determine whether the embryos have some kind of genetic abnormality that compromises their genetic material. Once the affected ones are detected, they will be dismissed.

    The chances for IVF with PGD to cause an ongoing pregnancy depend on the cause of recurrent miscarriage. If it were a genetic cause, it will depend on the odds of obtaining embryos without genetic abnormalities, too.

    On the other hand, as you mentioned, the cause of recurrent miscarriage can be due to immunological alterations that are causing your organism to reject the fetus, thereby leading to miscarriage. In this case, PGD would be effective only if the cause is determined by genetics or is a consequence of a genetic abnormality.

    In any case, examining the remaining tissues from your miscarriages would be interesting in order to find the cause or the reason behind them.

    I hope this helps,

    Best wishes

    01/09/2018 at 09:50
    #1117 Reply
  3. avatar

    Dear you are definitely going through much of a hard time right now facing a miscarriage is on its own so frustrating but you just have to hold on to everything. Rather than PGD, I would advise you to go for surrogacy as there are certain results. Hope for the best and just do not lose hope at all.

    08/25/2018 at 16:50
    #3097 Reply
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